Minimally Invasive Deep Inside the Body DSP Printing
The importance of combination of printing technologies and injectable biomaterial for the purpose of inside body printing has been introduced two decades ago. However, most of the cutting edge bioprinting technologies of today require open surgeries due to the fundamental limitation of the current printing methods that use heat or light as the energy source.
Direct Sound Printing (DSP) introduces a revolutionary approach to non-invasive bioprinting, enabling the fabrication of complex bio-constructs deep within the body without the need for surgery. Unlike traditional additive manufacturing methods that rely on light or heat, DSP leverages the unique ability of ultrasound waves to penetrate biological tissues and induce polymerization through acoustic cavitation. This capability allows for precise, in-situ printing of cellular and acellular scaffolds, implants, and therapeutic constructs within hard-to-reach areas of the body. By eliminating the need for invasive surgical procedures, DSP significantly reduces patient recovery times, lowers the risk of complications such as infection or tissue damage, and minimizes healthcare costs while enhancing overall treatment outcomes.
Sources:
- Habibi, M., Foroughi, S., Karamzadeh, V. et al. Direct sound printing. Nature Communications 13, 1800 (2022). https://www.nature.com/articles/s41467-022-29395-1
- Derayatifar, M., Habibi, et al. Holographic direct sound printing. Nature Communications 15, 6691 (2024). https://www.nature.com/articles/s41467-024-50923-8